PhysiologybioRxiv
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance
S. Skovso, E. Panzhinskiy, J. Kolic…·J. D. Johnson
This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.
DOI 10.1038/s41467-022-28039-8