J. D. Johnson

Regional cerebral arterial elasticity is associated with cardiovascular health in cognitively healthy older adults

This study examines the relationship between cerebral arterial elasticity and cardiovascular health in older adults, finding that higher cardiovascular risk burden is associated with lower cerebral arterial elasticity.

Region-specific associations between cerebral arterial elasticity and grey matter volume: Evidence for lateral prefrontal vulnerability

The paper investigates how regional cerebral arterial elasticity relates to grey matter volume decline with age, finding partial mediation in the left prefrontal cortex and sex-specific effects.

β-Hydroxybutyrate promotes basal insulin secretion while decreasing glucagon secretion in mouse and human islets.

This study shows that β-hydroxybutyrate (βHB) increases insulin secretion and decreases glucagon secretion in human and mouse islets at physiological glucose concentrations.

Pharmacological or genetic inhibition of Scn9a protects human and mouse beta cells while dampening insulin secretion in type 1 diabetes

This study shows that inhibiting Scn9a protects beta cells in type 1 diabetes by reducing excitability and improving survival, while also dampening insulin secretion.

Analysis of a genetic region affecting mouse body weight

This study investigates genetic factors affecting obesity in mice, identifying a region on chromosome 2 and exploring the role of Pdk1 and Itga6 in obesity and glucose metabolism.

Sex differences in islet stress responses support female beta cell resilience

This study identifies sex differences in beta cell stress responses, showing female beta cells are more resilient to ER stress in both human and mouse models.

Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation

Beta-cell Cre expression and reduced Ins1 gene dosage protect mice from type 1 diabetes

This study shows that beta-cell Cre expression and reduced Ins1 gene dosage protect NOD mice from type 1 diabetes, with Cre itself contributing additional protective effects.

Insulin receptor trafficking and interactions in muscle cells

This study investigates insulin receptor trafficking and interactions in muscle cells, identifying caveolin and clathrin-mediated pathways involved in receptor dynamics.

High resolution analysis of the cytosolic Ca2+ events in beta cell collectives in situ

This study measures Ca2+ dynamics in beta cell collectives using high-resolution imaging and a new computational framework, revealing three modes of Ca2+ event durations and the role of intracellular Ca2+ receptors.

Transcriptomic analysis of human and mouse muscle during hyperinsulinemia demonstrates insulin receptor downregulation as a mechanism for insulin resistance

The paper investigates how prolonged insulin exposure affects muscle cells, finding that reduced insulin receptor expression contributes to insulin resistance.

Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics

This study uses single-cell transcriptomics to show hyperinsulinemia affects pancreatic cancer development and immune microenvironment by altering immune cell pathways and reducing pre-cancerous lesions.

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition.

This study shows EIF2A protects pancreatic beta cells from ER stress by rescuing translation inhibition and reducing apoptosis.

A new hypothesis for type 1 diabetes risk: The at-risk allele at rs3842753 associates with increased beta cell INS mRNA in a meta-analysis of single cell RNA sequencing data

This study finds that the rs3842753 C allele is associated with higher INS mRNA and ER stress in beta cells, suggesting a link between genetic variation and beta cell dysfunction in type 1 diabetes.

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.

Breast cancer endocrine therapy exhausts adipocyte progenitors promoting weight gain and glucose intolerance

This study shows that breast cancer endocrine therapies deplete adipocyte progenitors and promote weight gain and glucose intolerance, especially in obese mice.

Differential effects of voclosporin and tacrolimus on insulin secretion from human islets

This study compares the effects of voclosporin and tacrolimus on insulin secretion from human islets, finding that tacrolimus impairs insulin secretion while voclosporin does not.

Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice

This study shows that reducing insulin in mice increases oxidative mitochondrial proteins in inguinal white adipose tissue and upregulates Ucp1 in mesenteric WAT and BAT under high-fat diet conditions.

Plumage redness signals mitochondrial function in the House Finch

The paper links carotenoid oxidation and feather redness to mitochondrial function in house finches, showing a direct relationship between mitochondrial performance and feather coloration.

Endogenous insulin contributes to pancreatic cancer development

This study shows that reducing endogenous insulin production decreases pancreatic cancer precursors in mice, suggesting insulin hypersecretion contributes to pancreatic cancer development.