Mapping Protein Dynamics at High-Resolution with Temperature-Jump X-ray Crystallography
A. M. Wolff, E. Nango, I. D. Young, A. S. Brewster, M. Kubo, T. Nomura, M. Sugahara, S. Owada, B. A. Barad, K. Ito, A. Bhowmick, S. Carbajo, T. Hino, J. M. Holton, D. Im, , M. C. Thompson
This study uses temperature-jump X-ray crystallography to observe atomic-scale protein motions in lysozyme, showing how vibrations evolve into functional movements and how inhibitors alter these dynamics.
bioRxiv · Jun 10, 2022Biophysics