K. Ito

Inosine Triphosphate Pyrophosphatase as a Candidate Associated with White Matter Abnormalities in Chronic Heart Failure

This study identifies inosine triphosphate pyrophosphatase (ITPA) as a candidate factor linking chronic heart failure and white matter abnormalities through human, animal, and cellular analyses.

Comparative genomic analysis of Latilactobacillus sakei strains provides new insights into their association with different niche adaptations

This study analyzes 30 L. sakei genomes to identify genetic mechanisms underlying niche adaptations, revealing core genome conservation, plasmid-mediated metabolic diversity, and potential probiotic applications.

The Calmodulin-like proteins, CML13 and CML14 Function as Myosin Light Chains for the Class XI Myosins in Arabidopsis

This paper identifies CML13 and CML14 as novel myosin XI light chains in Arabidopsis, showing they bind to myosin XI IQ domains and function in actin motility and root development.

From Soil to Surface: Exploring the Impact of Green Infrastructure on Microbial Communities in the Built Environment

The study examines how landscape design in a Tokyo museum affects microbial diversity and function, finding higher diversity but no consistent patterns in virulence or resistance genes.

Cellulose Rich Food Leads Anxiety through Gut-Brain Axis-mediated Amygdalar Dopamine Upregulation.

This study shows that a cellulose-rich diet increases anxiety in mice through gut-brain axis mechanisms involving amygdalar dopamine upregulation and opioidergic system activation.

Comparative analysis based on shared amplicon sequence variants reveals that cohabitation influences gut microbiota sharing between humans and dogs

This study shows that gut microbes are shared between humans and dogs, with some ASVs being highly abundant and possibly influencing bacterial transfer between hosts.

Myc upregulates Ggct, γ-glutamylcyclotransferase to promote development of p53-deficient osteosarcoma

The paper identifies GGCT as a Myc-target gene that promotes p53-deficient osteosarcoma development and suggests it as a potential therapeutic target.

Impact of rice GENERAL REGULATORY FACTOR14h (GF14h) on low-temperature seed germination and its application to breeding

This paper identifies GF14h as the causal gene for low-temperature seed germination in rice and demonstrates its utility in breeding for direct seeding in cold climates.

The similarities in microbial and chemical patterns of fermentation in two open environments were promoted by using 150-year-old Nukadoko as starters.

The study tracks microbial and chemical changes in two open environments using 150-year-old nukadoko as a starter, showing similar fermentation patterns driven by Loigolactobacillus.

Synaptic plasticity in the medial preoptic area of male mice encodes social experiences with female and regulates behavior toward young

This study identifies synaptic plasticity in the medial preoptic area of male mice as critical for shifting from aggressive to paternal behavior after mating and interaction with pups.

Culture system for longitudinal monitoring of bone remodeling ex vivo

This study develops an ex vivo culture system with longitudinal micro-CT scanning to monitor bone remodeling in osteochondral explants, revealing enhanced bone formation under dynamic compression.

Bacterial composition changes in canine plaque over periodontal disease severity and daily care practices

This study examines how bacterial composition in canine plaque changes with periodontal disease severity and daily care practices, finding increased Porphyromonas and decreased Conchiformibius with disease progression and improved outcomes with dental gel brushing.

Integration of Osteoclastogenesis through addition of PBMCs in Human Osteochondral Explants cultured Ex vivo

This study shows that adding PBMCs to human osteochondral explants enhances osteoclast activity and resorption, suggesting the need for external osteoclast precursors in long-term bone remodeling cultures.

Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemia

The paper identifies lineage-specific therapeutic vulnerabilities in AML subtypes using a two-group comparison approach based on genetic data from the Cancer Dependency Map.

Phylogeographical evidence for historical long-distance dispersal in the flightless stick insect Ramulus mikado

The paper investigates historical avian-mediated dispersal in Ramulus mikado stick insects using molecular data, finding low genetic differentiation and identical genotypes across distant populations.

Functional Characterization of Calmodulin-like Proteins, CML13 and CML14, as Novel Light Chains of Arabidopsis Class VIII Myosins

This study identifies CML13 and CML14 as novel light chains of Arabidopsis class VIII myosins through in vivo and in vitro assays.

A dialysis medium refreshment cell culture set-up for an osteoblast-osteoclast coculture

This study develops a dialysis-based cell culture system for osteoblast-osteoclast cocultures, showing increased osteoblastic and osteoclastic activity compared to standard methods.

Towards bone-remodeling-on-a-chip: self-assembling 3D osteoblast-osteoclast coculture in a microfluidic chip

This paper presents a 3D microfluidic coculture model of human bone remodeling using osteoblasts and osteoclasts, enabling long-term in vitro studies for drug testing.

Butyrate, valerate, and niacin ameliorate anaphylaxis by suppressing IgE-dependent mast cell activation: Roles of GPR109A, PGE2, and epigenetic regulation

This study shows that butyrate and valerate reduce IgE-mediated mast cell activation by enhancing PGE2 release and GPR109A signaling, while niacin also alleviates anaphylaxis through similar mechanisms.

Physiological reprogramming in vivo mediated by Sox4 pioneer factor activity

This study shows Sox4 initiates hepatobiliary metaplasia by first closing hepatocyte enhancers and then opening biliary enhancers in adult liver cells.

Towards development of serum substitute medium to induce osteoclast differentiation of human peripheral blood derived monocytes

This paper develops a serum substitute medium to support osteoclast differentiation from human peripheral blood monocytes, achieving all functional markers after 21 days of culture.

Matrix vesicle isolation from a three-dimensional in vitro bone model

This study isolates and characterizes matrix vesicles from a 3D in vitro bone model, showing they resemble natural matrix vesicles and could be used for bone regeneration.

A dark matter in sake brewing: Origin of microbes producing a Kimoto-style fermentation starter

This study identifies the microbial sources in Kimoto-style sake fermentation by analyzing environmental samples and fermentation starters.

The impact of culture variables on 3D human in vitro bone remodeling; a design of experiments approach

This study evaluates how culture variables affect in vitro human bone remodeling models using a design of experiments approach to improve reproducibility and translatability.

Functional characterization of Botrytis cinerea ABC transporter gene BcatrB in response to phytoalexins produced in plants belonging to families Solanaceae, Brassicaceae and Fabaceae

This study identifies BcatrB as a key transporter gene in Botrytis cinerea that mediates resistance to phytoalexins from Solanaceae, Brassicaceae, and Fabaceae plants.

Development of serum substitute medium for bone tissue engineering

This study develops a serum substitute medium for bone tissue engineering that performs as well as fetal bovine serum in cell attachment, survival, and matrix deposition under mechanical stress.

A unique case in which Kimoto-style fermentation was completed with Leuconostoc as the dominant genus without transitioning to Lactobacillus.

The paper characterizes a unique Kimoto-style fermentation process where Leuconostoc dominates without transitioning to Lactobacillus, differing from previously reported microbial patterns.

Characterization of three-dimensional bone-like tissue growth and organization under influence of curvature and directional fluid flow

This study evaluates how curvature and directional fluid flow affect three-dimensional bone-like tissue growth and organization using human mesenchymal stromal cells in a concave channel scaffold.

Evaluating material-driven regeneration in a tissue engineered human in vitro bone defect model

This study develops an in vitro human bone defect model to evaluate material-driven regeneration using tissue engineering, observing vascular-like network growth and bone-like tissue formation.

Tuning the resorption-formation balance in an in vitro 3D osteoblast-osteoclast co-culture model of bone

This study tunes an in vitro 3D osteoblast-osteoclast co-culture model to simulate bone formation, resorption, and equilibrium states using different culture media and monocyte seeding densities.