M. Kubo

Mapping Protein Dynamics at High-Resolution with Temperature-Jump X-ray Crystallography

This study uses temperature-jump X-ray crystallography to observe atomic-scale protein motions in lysozyme, showing how vibrations evolve into functional movements and how inhibitors alter these dynamics.

The molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain

This study identifies an autoinhibitory WW-like domain in USP8 that regulates its enzyme activity and links its release to Cushings disease.

Combined landscape of single-nucleotide variants and copy-number alterations in clonal hematopoiesis

The paper combines SNVs/indels and CNAs analysis in CH to show their co-occurrence and impact on health outcomes.

Carbon Assimilation Strategies in Ultrabasic Groundwater: Clues from the Integrated Study of a Serpentinization-Influenced Aquifer

The paper identifies carbon assimilation strategies in serpentinite-hosted microbial communities using metagenomics, metatranscriptomics, and metabolomics data from a subsurface aquifer.

Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals

This study compares serial X-ray crystallography and MicroED for determining structures from small macromolecular crystals, highlighting their strengths and challenges.

Origination of the circadian clock system in stem cells regulates cell differentiation in Arabidopsis thaliana.

The paper shows that the circadian clock in Arabidopsis stem cells regulates cell differentiation through BES1-mediated repression of LHY.

MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

This study identifies MIR2052HG's role in regulating LMTK3 and ERα levels, contributing to aromatase inhibitor resistance in breast cancer.

Single-cell transcriptome analysis of Physcomitrella leaf cells during reprogramming using microcapillary manipulation

The paper introduces 1cell-DGE, a single-cell RNA-sequencing method using microcapillary manipulation to analyze gene expression in intact moss tissues, identifying differentially expressed genes during leaf cell reprogramming.