Author

D. J. Brenner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Bioengineering· 2 Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 5 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

I. Shuryak· 5 shared D. Welch· 4 shared g. Garty· 4 shared H. C. Turner· 3 shared M. Buonanno· 3 shared B. Ponnaiya· 2 shared M. Repin· 2 shared M. Taveras· 2 shared

Activity by Year

2017-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersBioengineering

I. Shuryak

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Ocular and Facial Far-UVC Doses from Ceiling-Mounted 222 nm Far-UVC Fixtures

M. A. Duncan, D. Welch, I. Shuryak, D. J. Brenner

This study measures ocular and facial far-UVC exposure doses from ceiling-mounted 222 nm fixtures using a manikin, finding eye doses are 5.8% of the maximum measured dose.

bioRxiv · May 9, 2022Bioengineering

No evidence of induced skin cancer or other skin abnormalities after long term (66 week) chronic exposure to 222-nm far-UVC radiatio

D. Welch, N. J. Kleiman, P. C. Arden, C. L. Kuryla, M. Buonanno, B. Ponnaiya, X. Wu, D. J. Brenner

This study shows no evidence of skin cancer or abnormalities in mice after 66 weeks of far-UVC exposure, supporting its long-term safety.

bioRxiv · Mar 16, 2022Cancer Biology

LET-dependence of radiation-induced makers of Immunogenic Cell Death in human cancer cell lines

B. Ponnaiya, A. Lomastro, P. W. Grabham, g. Garty, A. D. Harken, S. A. Amundson, E. M. C. Hillman, D. J. Brenner

This study examines how the linear energy transfer (LET) of radiation affects the expression of immunogenic cell death markers in human cancer cell lines, finding cell-specific variations in responses.

bioRxiv · Jan 25, 2022 · PreprintCell Biology

Wavelength-dependent DNA photodamage in a 3-D human skin model over the far-UVC and germicidal-UVC wavelength ranges from 215 to 255 nm

D. Welch, M. Aquino de Muro, M. Buonanno, D. J. Brenner

This study assesses wavelength-dependent DNA damage in a 3-D human skin model exposed to UVC light from 215 to 255 nm, finding no damage at 215-235 nm but significant damage at 240-255 nm.

bioRxiv · Dec 14, 2021Biophysics

DNA damage response in peripheral mouse blood leukocytes in vivo after variable, low-dose rate exposure

Q. Wang, M. C. Pujol, M. Taveras, J. Perrier, C. Bueno-Beti, I. Shuryak, D. J. Brenner, H. C. Turner

This study investigates the DNA damage response in mouse peripheral blood leukocytes after variable, low-dose rate 137Cs exposure using a novel irradiation device, finding that γ-H2AX levels correlate with accumulated dose and could serve as a biomarker for radiation dosimetry.

bioRxiv · May 24, 2019 · PreprintCell Biology

New High Throughput Approaches to Detect Partial-body and Neutron Exposures on an Individual Basis

I. Shuryak, H. C. Turner, J. R. Perrier, L. Cunha, M. Pujol Canadell, M. H. Durrani, A. Harken, A. Bertucci, M. Taveras, G. Garty, D. J. Brenner

This study develops a high-throughput biomarker approach to detect partial-body and neutron exposures using micronuclei distribution metrics in lymphocytes, achieving high accuracy in distinguishing exposure types.

bioRxiv · May 23, 2019 · PreprintBiophysics

Development of a high-throughput γ-H2AX assay based on imaging flow cytometry

Y. Lee, Q. Wang, I. Shuryak, D. J. Brenner, H. C. Turner

The paper develops a high-throughput γ-H2AX assay using imaging flow cytometry to measure DNA double-strand break repair kinetics in human blood cells after ionizing irradiation.

bioRxiv · May 15, 2019Cell Biology

The use of a centrifuge-free RABiT-II system for high-throughput micronucleus analysis

M. Repin, S. Y. Pampou, D. J. Brenner, G. Garty

The paper describes a centrifuge-free adaptation of the CBMN assay for high-throughput systems, enhancing automation potential for biodosimetry.

bioRxiv · May 4, 2019Cell Biology

A new approach to automated CBMN scoring following high doses

M. Repin, D. J. Brenner, G. Garty

The paper describes an automated method for scoring the CBMN assay that adjusts for mitotic delay at high doses, resulting in a monotonic dose response curve.

bioRxiv · Apr 30, 2019 · PreprintCell Biology

Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases

D. Welch, M. Buonanno, V. Grilj, I. Shuryak, C. Crickmore, A. W. Bigelow, G. Randers-Pehrson, G. W. Johnson, D. J. Brenner

The paper demonstrates that far-UVC light can effectively inactivate airborne aerosolized viruses while being safe for human skin and eyes.

bioRxiv · Dec 28, 2017Bioengineering