The epithelial-mesenchymal transcription factor SNAI1 represses transcription of the tumor suppressor miRNA let-7 in cancer
H. Wang, E. Chirshev, N. Hojo, T. Suzuki, A. Bertucci, M. Pierce, C. Perry, R. Wang, J. I. Zink, C. Glackin, Y. Ioffe, J. Unternaehrer
This study shows SNAI1 represses let-7 miRNA, promoting stemness in cancer cells, and demonstrates nanoparticle-mediated SNAI1 knockdown reduces tumor burden.
bioRxiv · Nov 4, 2020Cancer Biology