Evolutionary BiologybioRxiv
Effective polyploidy causes phenotypic delay and influences bacterial evolvability
L. Sun, H. K. Alexander, B. Bogos…·S. Bonhoeffer
This study shows antibiotic resistance mutations in E. coli have a 3-4 generation phenotypic delay due to effective polyploidy, impacting mutation rate estimation and evolutionary adaptation.
DOI 10.1371/journal.pbio.2004644