BiochemistrybioRxiv
Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating JMJD3
Z. Saiioum, K. Dauner, Y.-f. Li…·X. Zha
This study shows statins reduce macrophage cholesterol, upregulate JMJD3, and shift macrophage activation toward anti-inflammatory responses in both M1 and M2 states.
DOI 10.7554/elife.85964