The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming
A. Sardinha-Silva, F. C. Mendonca-Natividade, C. F. Pinzan, C. D. Lopes, D. L. Costa, D. Jacot, F. F. Fernandes, A. L. V. Zorzetto-Fernandes, N. J. Gay, A. Sher, D. Jankovic, D. Soldati-Favre, M. E. Grigg, M. C. Roque-Barreira
This paper shows that Toxoplasma gondii microneme proteins MIC1 and MIC4 bind TLR2 and TLR4 N-glycans to activate innate immune responses and regulate infection outcomes.
bioRxiv · Jun 13, 2019Immunology