Mapping the S1 and S1 subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents
L. Cianni, C. Lemke, E. Gilberg, C. Feldmann, F. Rosini, F. d. R. Rocho, J. F. R. Ribeiro, D. Y. Tezuka, C. D. Lopes, S. de Albuquerque, J. Bajorath, A. Leitao, S. Laufer, M. Gütschow, C. A. Montanari
The paper designs and tests 26 dipeptidyl nitrile inhibitors against cysteine proteases to map their S1/S1' subsites and identify potential trypanocidal agents.
bioRxiv · Sep 8, 2019Biochemistry