Discovery of a novel human antibody VH domain with potent activity against mesothelin expressing cancer cells in both CAR T-cell and antibody drug conjugate formats
Z. Sun, X. Chu, C. Adams, T. V. Ilina, C. Chen, D. Jelev, R. Ishima, W. Li, J. W. Mellors, G. Calero, D. S. Dimitrov
The paper identifies a novel human antibody VH domain with high affinity for mesothelin and demonstrates its efficacy in both CAR-T cell and antibody drug conjugate formats against mesothelin-expressing cancer cells.
bioRxiv · Apr 7, 2022 · PreprintCancer Biology