Z. Sun

Multi-omic profiling of intraductal papillary neoplasms of the pancreas reveals distinct expression patterns and potential markers of progression

This study profiles proteins and glycoproteins in pancreatic neoplasms to identify expression patterns and potential progression markers.

Post-flowering photoperiod sensitivity of soybean in pod-setting responses

This study shows that soybean pod formation is sensitive to photoperiod, with LD conditions delaying pod formation and SD conditions affecting pistil morphology to influence pod-setting timing.

An orphan viral genome with controversial evolutionary status sheds light on a distinct lineage of flavi-like virus infecting plants

This study resolves the taxonomic controversy of SRAV, a plant-infecting flavi-like virus, by showing it belongs to the Flaviviridae family and triggers host RNAi responses.

Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model

The paper investigates how exercise affects Alzheimer's disease in mice by analyzing gene expression and chromatin changes, finding that growth factor signaling pathways are key to exercise's benefits.

Rational Design of Live Biotherapeutic Products for the Prevention of Clostridioides difficile Infection

This study uses computational methods and metagenomic data to identify microbial strains that can inhibit CDI, supporting the design of live biotherapeutic products.

Mammalian Cell Models of the Distal Convoluted Tubule: A Systematic Review of Cell Lines, Culture Condition and Gene Expression

This review summarizes human, murine, and canine DCT cell models, their culture conditions, and gene expression, highlighting methodological inconsistencies and gaps in reporting.

The Alexander Disease Protein GFAP Drives Mitochondrial Fission

This study identifies GFAP as a novel mediator of mitochondrial fission by surrounding fission sites and modulating Drp1 recruitment, revealing a new mechanism in mitochondrial plasticity.

Highly efficient in vivo mutagenesis method based on the endonuclease and exonuclease activity of Bacillus alcalophilus RecJ (BaRecJ)

This paper introduces a novel mutagenesis method using BaRecJ's endonuclease and exonuclease activities, showing broader mutation spectra and improved trait-associated gene identification in E. coli and S. cerevisiae.

Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment

The paper develops JQ1-alkenyl oxindole conjugates that degrade BRD4 via the ubiquitin-proteasome system and recruits CRL4DCAF11, identifying HL435 as a potent antitumor lead.

Current research on epigenetic age and cellular senescence: a bibliometric and visual analysis

This study uses bibliometric analysis to map research trends on epigenetic age and cellular senescence, identifying key clusters and shifts in focus toward mechanisms and therapies.

Nanoscale Structure, Interactions, and Dynamics of Centromere Nucleosomes

This study uses AFM to analyze the nanoscale structure and dynamics of CENP-A and canonical H3 nucleosomes, revealing differences in internucleosomal interactions and DNA unwrapping behavior.

Cell Type Specific Responses of the Endoplasmic Reticulum Dynamics to Environmental Stress

This study develops a super-resolution imaging and analysis method to study ER dynamics in Arabidopsis under environmental stress, revealing correlations between ER structure parameters and growth features.

STING Licensing of Type I Dendritic Cells Potentiates Antitumor Immunity

A 'shock-and-lock' nanoparticle agonist activates STING in type 1 conventional dendritic cells to enhance antitumor immunity with associated biomarkers.

The Zea mays PeptideAtlas; a new maize community resource

The paper develops the Maize PeptideAtlas resource to analyze maize proteomes using MS/MS data, identifying peptides and proteins across diverse genetic backgrounds and conditions.

How to barcode (almost all) freshwater biodiversity

This study identifies cost-effective primer pairs and develops a tool to enhance eDNA-based monitoring of freshwater biodiversity.

Activation of the mitochondrial unfolded protein response regulates the formation of stress granules

The paper shows that the mitochondrial unfolded protein response (UPRmt) interacts with stress granules (SGs) to regulate cellular stress responses and mitochondrial homeostasis.

Endothelial Cell Serum and Glucocorticoid Regulated Kinase 1 (SGK1) Mediates Vascular Stiffening

This study investigates the role of endothelial cell SGK1 in vascular stiffening, finding that its inhibition reduces stiffness in both mouse models and human endothelial cells.

NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer

This study identifies NSD2 as a key driver of lineage plasticity and castration-resistance in neuroendocrine prostate cancer, showing its inhibition can restore sensitivity to AR inhibitors.

Detection and editing of the updated plastid- and mitochondrial-encoded proteomes for Arabidopsis with PeptideAtlas

This study identifies and analyzes RNA editing sites in plastid and mitochondrial proteomes of Arabidopsis using mass spectrometry data from PeptideAtlas.

Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme research

The paper constructs a proteome resource, Borrelia PeptideAtlas, by integrating transcriptomic and proteomic data from multiple B. burgdorferi isolates to identify common proteins across infective strains.

Mapping the Arabidopsis thaliana proteome in PeptideAtlas and the nature of the unobserved (dark) proteome; strategies towards a complete proteome

This paper updates the Arabidopsis thaliana PeptideAtlas proteomics resource, identifies 78.6% of the predicted proteome, and uses a machine learning model to predict the dark proteome.

Molecular motor tug-of-war regulates elongasome cell wall synthesis dynamics in Bacillus subtilis

This study tracks elongasome dynamics in Bacillus subtilis using single molecule fluorescence microscopy and shows molecular motor tug-of-war regulates processivity and termination events.

Photosynthetic living fibers fabrication from algal-bacterial consortia with controlled spatial distribution

This paper develops a co-culture platform to create photosynthetic living fibers using algal-bacterial consortia with controlled spatial distribution for bioremediation and advanced materials.

Multiplexed Sequential Imaging in Living Cells with Orthogonal Fluorogenic RNA Aptamer/Dye Pairs

This paper introduces seqFRIES, a method for multiplexed live-cell imaging using orthogonal RNA aptamer/dye pairs, achieving four-color imaging in ~20 minutes.

β1 integrin signaling governs necroptosis via the chromatin remodeling factor CHD4

The paper shows that β1 integrin signaling regulates necroptosis through CHD4-mediated repression of Ripk3 in fibrosis.

Liproxstatin-1 alleviates cartilage degradation by inhibiting chondrocyte ferroptosis in temporomandibular joint

This study shows that ferroptosis contributes to TMJOA cartilage degradation and that Lip-1 inhibits this process by reducing ferroptosis markers and oxidative stress in chondrocytes.

Targeted RNA Condensation in Living Cells via Genetically Encodable Triplet Repeat Tags

This study introduces a genetically encoded RNA tag to program RNA condensate formation and modulate RNA localization and function in living cells.

Toxoplasma gondii infection alters the recognition response of dendritic cells to stiffness substrate: A new model of cell durotaxis migration

This paper shows that Toxoplasma gondii infection changes dendritic cell durotaxis by altering F-actin structure and FAK phosphorylation, promoting parasite brain dissemination.

Identifying keystone species in microbial communities using deep learning

This paper introduces a deep learning framework to identify keystone species in microbial communities using synthetic and real microbiome data, finding taxa with high keystoneness show community specificity.

Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis

This study identifies cross-reactive intrahepatic antibodies in severe alcoholic hepatitis that target both bacterial antigens and human proteins, suggesting a role in disease pathogenesis.