Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism
F. Magnotti, D. Chirita, S. Dalmon, A. Martin, P. Bronnec, J. Sousa, o. Helynck, W. Lee, D. Kastner, J. J. Chae, M. McDermott, a. Belot, M. Popoff, P. Seve, S. Georgin-Lavialle, , T. Henry
This study identifies steroid hormone catabolites as specific activators of the pyrin inflammasome through a non-canonical mechanism, linking them to autoinflammation and explaining steroid fever.
bioRxiv · Oct 29, 2021Immunology