ImmunologybioRxiv
Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism
F. Magnotti, D. Chirita, S. Dalmon…·T. Henry
This study identifies steroid hormone catabolites as specific activators of the pyrin inflammasome through a non-canonical mechanism, linking them to autoinflammation and explaining steroid fever.
DOI 10.1016/j.celrep.2022.111472