Author

T. Henry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 7 Research Focus:host-pathogen & immune response· 6 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

A. Belot· 2 shared F. Magnotti· 2 shared S. Georgin-Lavialle· 2 shared Y. Jamilloux· 2 shared A. CHARBIT· 1 shared A. Conde· 1 shared A. Duquesne· 1 shared A. JAMET· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

A. Belot

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Functional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation.

C. Cosson, R. Riou, D. Patoli, T. Niu, A. Rey, M. Groslambert, E. Chatre, O. Allatif, T. Henry, F. Venet, F. Milhavet, G. Boursier, A. Belot, Y. Jamilloux, E. Merlin, , B. F. Py

This study functionally characterizes 34 NLRP3 variants associated with CAPS, identifying functional diversity and inhibitor sensitivity, with implications for diagnosis and drug development.

bioRxiv · Sep 22, 2023 · PreprintImmunology

Phosphoprotein Phosphatase Activity Positively Regulates Oligomeric Pyrin to Trigger Inflammasome Assembly in Phagocytes

H. S. Malek, F. Magnotti, N. A. Loeven, J. M. Delgado, A. N. Kettenbach, T. Henry, J. B. Bliska

This study identifies phosphoprotein phosphatase activity as a positive regulator of oligomeric pyrin, essential for inflammasome assembly in phagocytes.

bioRxiv · Mar 23, 2022Immunology

Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

F. Magnotti, D. Chirita, S. Dalmon, A. Martin, P. Bronnec, J. Sousa, o. Helynck, W. Lee, D. Kastner, J. J. Chae, M. McDermott, a. Belot, M. Popoff, P. Seve, S. Georgin-Lavialle, , T. Henry

This study identifies steroid hormone catabolites as specific activators of the pyrin inflammasome through a non-canonical mechanism, linking them to autoinflammation and explaining steroid fever.

bioRxiv · Oct 29, 2021Immunology

Design, 3D-printing, and characterisation of a low-cost, open-source centrifuge adaptor for separating large volume clinical blood samples

M. E. Haque, N. Naeem, T. Henry, L. Marriott, A. Conde, M. Kersaudy-Kerhoas

The paper designs and tests a low-cost centrifuge adaptor for separating large blood samples, achieving performance comparable to expensive centrifuges.

bioRxiv · Oct 19, 2021 · PreprintBioengineering

Bacterial factors drive the differential targeting of Guanylate Binding Proteins to Francisella and Shigella

S. V. VALEVA, F. Michal, M. Degabriel, J. R. Rohde, F. Randow, R. K. Ernst, B. Lagrange, T. Henry

This study identifies bacterial factors, including lipid A structure, that influence the differential targeting of GBPs to Francisella and Shigella.

bioRxiv · Jun 16, 2021Microbiology

The inflammasome components NLRP3 and ASC act in concert with IRGM to rearrange the Golgi during viral infections

C. F. Daussy, S. C. Monard, C. Guy, S. Munoz-Gonzalez, M. Chazal, M. W. Anthonsen, n. jouvenet, T. Henry, M. - DREUX, E. F. Meurs, M. D. Hansen

The paper shows NLRP3 and ASC work with IRGM to rearrange the Golgi during viral infections like HCV and ZIKV.

bioRxiv · Apr 27, 2020Microbiology

Bacterial immune evasion proteins: The therapeutic potential of CHIPS

A. Tromp, Y. Zhao, I. Jongerius, E. C. Heezius, P. Abrial, M. Ruyken, J. van Strijp, C. J. C. de Haas, A. Spaan, K. P. M. van Kessel, T. Henry, P.-J. A. Haas

This study evaluates CHIPS as a therapeutic agent for inflammation, showing promise in mice but safety concerns in humans due to pre-existing antibodies.

bioRxiv · Feb 25, 2020 · PreprintMicrobiology

A post-translational modification of the sheath 1 modulates Francisella type VI secretion system assembly and function

J. ZIVERI, C. CCHUON, A. JAMET, G. PRIGENT, H. RYTTER, F. TROS, M. BAREL, m. COUREUIL, C. LAYS, t. HENRY, N. KEEP, C. I. GUERRERA, A. CHARBIT

This study identifies a phosphorylation site on IglB that modulates Francisella T6SS assembly and function, showing that phosphorylation is critical for sheath stability and phagosomal escape.

bioRxiv · Feb 22, 2019 · PreprintMicrobiology