Author

J. Sousa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Bardelli· 1 shared a. Belot· 1 shared A. Martin· 1 shared A. U. Lindner· 1 shared C. J. Scott· 1 shared C. Latimer· 1 shared C. Winnington· 1 shared C. Wouters· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Bardelli

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Bcl-xL is a key mediator of apoptosis following KRASG12C inhibition in KRASG12C mutant colorectal cancer.

H. Khawaja, R. Briggs, C. Latimer, M. Rassel, D. Griffin, L. Hanson, A. Bardelli, F. Di Nicolantonio, S. S. McDade, C. J. Scott, S. Lambe, M. Maurya, A. U. Lindner, J. H. M. Prehn, J. Sousa, , S. Van Schaeybroeck

This study identifies Bcl-xL as a mediator of resistance to KRASG12C inhibitors in colorectal cancer and shows that combining Bcl-xL inhibition with KRASG12C inhibition enhances apoptosis and reduces tumor growth.

bioRxiv · May 10, 2022Cancer Biology

Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

F. Magnotti, D. Chirita, S. Dalmon, A. Martin, P. Bronnec, J. Sousa, o. Helynck, W. Lee, D. Kastner, J. J. Chae, M. McDermott, a. Belot, M. Popoff, P. Seve, S. Georgin-Lavialle, , T. Henry

This study identifies steroid hormone catabolites as specific activators of the pyrin inflammasome through a non-canonical mechanism, linking them to autoinflammation and explaining steroid fever.

bioRxiv · Oct 29, 2021Immunology