Depressive-like behaviors induced by somatostatin-positive GABA neuron silencing are rescued by alpha 5 GABA-A receptor potentiation
C. Fee, T. D. Prevot, K. A. Misquitta, D. Knutson, G. Li, J. Cook, M. A. Banasr, E. Sibille
This paper shows that silencing somatostatin-positive GABA neurons in mice induces depressive-like behaviors, which are reversed by a 5-GABA-A receptor positive allosteric modulator.
bioRxiv · Oct 5, 2020Pharmacology & Toxicology