E. Sibille

Procognitive and neurotrophic benefits of α5-GABA-A receptor positive allosteric modulation in a beta-amyloid deposition model of Alzheimer's disease pathology

This study shows that GL-II-73, a 5-GABAAR positive allosteric modulator, improves cognitive function and neuronal structure in Alzheimer's disease models despite beta-amyloid accumulation.

Chronic Stress Alters Astrocyte Morphology in Mouse Prefrontal Cortex

This study shows chronic stress causes astrocyte atrophy in mouse prefrontal cortex, linked to anhedonia but not anxiety-like behaviors.

Depressive-like behaviors induced by somatostatin-positive GABA neuron silencing are rescued by alpha 5 GABA-A receptor potentiation

This paper shows that silencing somatostatin-positive GABA neurons in mice induces depressive-like behaviors, which are reversed by a 5-GABA-A receptor positive allosteric modulator.

Prophylactic efficacy of riluzole against anxiety- and depressive-like behaviors in two rodent stress models

This study evaluates riluzole's prophylactic effects against anxiety- and depressive-like behaviors in rodent stress models, finding it reduces anhedonia and helplessness.

Residual avoidance: a new consistent and repeatable readout of chronic stress-induced conflict anxiety reversible by antidepressant treatment

This paper introduces a new behavioral assay, residual avoidance, to measure chronic stress-induced conflict anxiety in mice, showing it is consistent and reversible by antidepressants.