J. Cook

Classification of Variants of Reduced Penetrance in High Penetrance Cancer Susceptibility Genes: Framework for Genetics Clinicians and Clinical Scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK)

The paper develops a framework for classifying variants of reduced penetrance in cancer susceptibility genes to improve variant interpretation consistency.

Piezo inhibition prevents and rescues scarring by targeting the adipocyte to fibroblast transition

This study shows that inhibiting Piezo1 or Piezo2 prevents adipocyte-to-fibroblast transition, reducing scarring in wounds and suggesting a therapeutic target for fibrosis.

Gut microbial diversity in stingless bees is linked to host wing size and is influenced by geography

This study analyzes the gut microbiomes of two stingless bee species, finding that bacterial richness in T. carbonaria correlates with host wing size and geography.

Thermodynamic constraints on the assembly and diversity of microbial ecosystems are different near to and far from equilibrium

This paper develops a thermodynamic microbial community model to study how free-energy availability and reaction reversibility affect community diversity and interaction types.

Positive modulation of cerebellar α6GABAA receptors for treating essential tremor: a proof-of-concept study in harmaline-treated mice

This study evaluates 6GABAAR-selective PAMs for treating essential tremor in harmaline-treated mice, finding they reduce tremor and restore burrowing activity.

The role of competition versus cooperation in microbial community coalescence

This study uses a consumer-resource model to show that less competitive and more cooperative microbial communities dominate coalescence outcomes and evolve to be more species-rich and efficient.

A Comprehensive Phylogenomic Platform for Exploring the Angiosperm Tree of Life

This paper introduces a phylogenomic platform for angiosperms, providing a large dataset and open tool for exploring the flowering plant tree of life.

Depressive-like behaviors induced by somatostatin-positive GABA neuron silencing are rescued by alpha 5 GABA-A receptor potentiation

This paper shows that silencing somatostatin-positive GABA neurons in mice induces depressive-like behaviors, which are reversed by a 5-GABA-A receptor positive allosteric modulator.

LRRC8A regulates hypotonicity-induced NLRP3 inflammasome activation

This study identifies LRRC8A as a key regulator of hypotonicity-induced NLRP3 inflammasome activation, distinct from DAMP-induced activation.

pHLARE: A Genetically Encoded Ratiometric Lysosome pH Biosensor

The paper introduces pHLARE, a genetically encoded ratiometric lysosome pH biosensor, and demonstrates its use in showing decreased lysosome pH in cancer cell lines.

Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence

The paper shows that human cells re-entering the cell cycle from quiescence have impaired p53-dependent origin licensing and slow MCM loading, leading to underlicensed first S phases and increased replication stress sensitivity.