Author

D. L. Lahr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Adam· 1 shared A. M. Taherbhoy· 1 shared B. Sherbanee· 1 shared C. P. Decicco· 1 shared D. Huang· 1 shared D. Mayhew· 1 shared D. S. Millan· 1 shared G. A. Smolen· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Adam

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Hijacking the transcriptional activation potential of the BAF complex via Induced Proximity

L. Chia, D. Mayhew, B. Sherbanee, D. L. Lahr, A. M. Taherbhoy

This study uses induced proximity to redirect BAF complexes to activate therapeutic genes, altering chromatin landscapes and identifying proliferation-suppressing genes.

bioRxiv · Dec 18, 2023 · PreprintCell Biology

Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

R. C. Centore, L. M. M. Soares, S. Topal, R. G. Vaswani, K. Ichikawa, Z. Li, H. Fan, J. W. Setser, D. L. Lahr, L. E. Zawadzke, X. Chen, K. D. Barnash, J. Muwanguzi, N. Anthony, G. J. Sandoval, , S. F. Bellon

This study identifies and characterizes inhibitors of SMARCA4/SMARCA2 ATPases, showing their ability to induce lineage-specific chromatin changes and tumor regression in uveal melanoma.

bioRxiv · Sep 11, 2023 · PreprintCancer Biology