A. Adam

A safe insect-based Chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques

This study evaluates an insect-based chimeric virus vaccine against Chikungunya fever, showing rapid and durable protection in macaques.

Modulation of Ideonella sakaiensis PETase active site flexibility and activity on morphologically distinct substrates by surface charge engineering

The paper investigates how surface charge mutations affect PETase activity on different PET substrates and identifies an engineered variant with improved degradation efficiency.

Decoration of Burkholderia Hcp1 protein to virus-like particles as a vaccine delivery platform.

This study conjugates Hcp1 protein to P22 VLPs to create a vaccine platform, inducing antibody responses and enhancing macrophage phagocytosis in mice.

A Murine Model of Post-acute Neurological Sequelae Following SARS-CoV-2 Variant Infection

This study uses a murine model to investigate persistent neurological symptoms after SARS-CoV-2 Delta variant infection, finding long-term immune activation and behavioral abnormalities.

Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

This study identifies and characterizes inhibitors of SMARCA4/SMARCA2 ATPases, showing their ability to induce lineage-specific chromatin changes and tumor regression in uveal melanoma.

A single-dose of intranasal vaccination with a live-attenuated SARS-CoV-2 vaccine candidate promotes protective mucosal and systemic immunity

Humoral and T-cell-mediated responses to a pre-clinical Zika vaccine candidate that utilizes a unique insect-specific flavivirus platform

This study evaluates immune responses to an ISFV-based Zika vaccine, showing neutralizing antibodies and T-cells contribute to protection.

The Resolvin D2-GPR18 Axis Enhances Bone Marrow Function and Limits Hepatic Fibrosis in Aging

This study shows that RvD2-GPR18 signaling reduces hepatic fibrosis and steatosis in aging by enhancing bone marrow function and macrophage populations.

The common oral parasitic protozoan Entamoeba gingivalis forms cysts in response to antibiotic treatment

This study shows that Entamoeba gingivalis forms cysts in response to antibiotic treatment, which may explain persistent periodontal tissue destruction.

Deep learning in human neurons predicts mechanistic subtypes of Parkinson's

This study uses deep learning on patient-derived neurons to predict Parkinson's disease subtypes with high accuracy, highlighting mitochondrial and lysosomal features as key predictors.

Changes of small non-coding RNAs by severe acute respiratory syndrome coronavirus 2 infection

This study identifies changes in small non-coding RNAs (sncRNAs) in SARS-CoV-2 infection, showing that tRFs and a viral-derived sncRNA (sv-CoV2-346) are significantly altered.

Combinatorial mRNA vaccination enhances protection against SARS-CoV-2 delta variant

This study shows that combining mRNA vaccines targeting the SARS-CoV-2 spike and nucleoprotein proteins enhances protection against the delta variant in animal models.

A modified porous silicon microparticle promotes mucosal delivery of SARS-CoV-2 antigen and induction of potent and durable systemic and mucosal T helper 1 skewed protective immunity