D. L. Levy

Epidermal cell fusion promotes the transition from an embryonic to a larval transcriptome in C. elegans

The paper shows that cell fusion in C. elegans epidermis drives transcriptomic changes from embryonic to larval state, with eff-1 mutants showing delayed progression.

Nuclear growth and import can be uncoupled

The paper shows nuclear growth and import can be uncoupled, suggesting chromatin mechanical properties drive nuclear growth rather than import alone.

Identification of epigenetic modulators as determinants of nuclear size and shape

This study identifies epigenetic modulators that influence nuclear size and shape through a high-throughput siRNA screen and biochemical analysis.

Nuclear Transport Factor 2 (NTF2) suppresses metastatic melanoma by modifying cell migration, metastasis, and gene expression

This study shows that increasing NTF2 expression in metastatic melanoma cells reduces proliferation, motility, and metastasis while increasing apoptosis and survival.

The perinuclear ER scales nuclear size independently of cell size in early embryos

The paper shows that nuclear size in early sea urchin embryos scales with perinuclear ER, not cell size, through dynein-mediated ER accumulation.

Rtn4a promotes exocytosis in mammalian cells while ER morphology does not necessarily affect exocytosis and translation

The paper shows Rtn4a enhances exocytosis without altering ER morphology, while changes in ER tubule-to-sheet ratio do not affect protein trafficking or translation.

Cytoplasmic volume and limiting nucleoplasmin scale nuclear size during Xenopus laevis development

The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity

This study identifies ELYS as a regulator of nuclear size by controlling NPC number and nuclear import capacity in mammalian cells.