Cerebrospinal fluid transcriptional analyses reveals upregulation of IL-17, Type 1 interferon transcriptional pathways and neutrophil persistence genes associated with increased mortality from pneumococcal meningitis in adults
E. C. Wall, J. A. Guerra-Assuncao, G. Pollara, C. Venturini, V. Mlowzowa, T. Allain, D. Lalloo, M. Noursadeghi, J. S. Brown, R. Heyderman
The paper identifies CSF gene expression patterns associated with increased mortality in pneumococcal meningitis, highlighting IL-17, Type 1 interferon, and neutrophil persistence pathways.
bioRxiv · Dec 7, 2018 · PreprintImmunology