M. Noursadeghi

Tribbles1 and Cop1 cooperate to protect the host during in vivo mycobacterial infection

This study identifies Trib1 and Cop1 as immune regulators that protect against mycobacterial infection by modulating macrophage function and inflammation.

Disease-attenuated pneumococcal biosynthesis gene mutants invade the mucosal epithelium and induce innate immunity

This paper shows that disease-attenuated pneumococcal mutants retain epithelial microinvasion but show reduced transmigration and altered inflammatory responses.

Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection.

The paper identifies high frequency naive T cell precursors that drive rapid T cell responses during early SARS-COV-2 and LCMV infections.

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

This study identifies that the B.1.1.7 SARS-CoV-2 variant enhances innate immune evasion through increased Orf9b and Orf6 expression and activity.

Aggregated Mycobacterium tuberculosis enhances the inflammatory response

The paper investigates how aggregated Mycobacterium tuberculosis triggers a stronger inflammatory response in macrophages compared to single or multiple non-aggregated bacilli.

HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells

This study shows HIV-1 infects resting memory T cells without prior activation, inducing a tissue-resident memory-like phenotype driven by Vpr.

SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation

This study shows SARS-CoV-2 activates RNA sensors in lung epithelial cells, driving macrophage inflammation, which can be mitigated by inhibiting RNA sensing or downstream signaling.

Exaggerated in vivo IL-17 responses discriminate recall responses in active TB

The paper shows that exaggerated IL-17A/F responses in active TB distinguish it from cured or latent TB, suggesting therapeutic targeting of this pathway.

Transcriptional response modules characterise IL-1β and IL-6 activity in COVID-19

The paper identifies IL-1β and IL-6 transcriptional response modules in COVID-19 and finds they reflect cytokine bioactivity without correlating with disease severity.

Epithelial micro-invasion by Streptococcus pneumoniae induces epithelial-derived innate immunity during colonisation at the human mucosal surface

This study shows that Streptococcus pneumoniae colonizes human mucosa via microinvasion, triggering epithelial innate immunity and influencing bacterial clearance.

Concise whole blood transcriptional signatures for incipient tuberculosis: A systematic review and patient-level pooled meta-analysis

This paper evaluates 17 mRNA signatures for predicting incipient tuberculosis using a pooled dataset of 1,026 samples, finding that eight signatures show moderate diagnostic accuracy but fall short of WHO benchmarks for long-term risk prediction.

Analysis tools to quantify dissemination of pathology in zebrafish larvae

The paper develops QuantiFish, an image analysis tool to quantify bacterial load and spatial distribution in zebrafish larvae infected with Mycobacterium marinum.

Viral infection enhances vomocytosis of intracellular fungi via Type I interferons

This paper shows that viral infection increases vomocytosis of Cryptococcus neoformans by macrophages through type-I interferons.

Cerebrospinal fluid transcriptional analyses reveals upregulation of IL-17, Type 1 interferon transcriptional pathways and neutrophil persistence genes associated with increased mortality from pneumococcal meningitis in adults

The paper identifies CSF gene expression patterns associated with increased mortality in pneumococcal meningitis, highlighting IL-17, Type 1 interferon, and neutrophil persistence pathways.