G. Pollara

Bacterial surface lipoproteins mediate epithelial microinvasion by Streptococcus pneumoniae

This study investigates how pneumococcal lipoproteins mediate epithelial microinvasion and finds that differential lipoprotein repertoires do not significantly impact microinvasion, suggesting post-translational modifications may be responsible.

Tribbles1 and Cop1 cooperate to protect the host during in vivo mycobacterial infection

This study identifies Trib1 and Cop1 as immune regulators that protect against mycobacterial infection by modulating macrophage function and inflammation.

Dysfunctional effector memory CD8 T cells in the bronchoalveolar compartment of people living with HIV

This study identifies dysfunctional effector memory CD8 T cells in the bronchoalveolar compartment of HIV-positive individuals, linked to reduced IL-17A production and increased regulatory molecule expression, contributing to susceptibility to tuberculosis.

Exaggerated in vivo IL-17 responses discriminate recall responses in active TB

The paper shows that exaggerated IL-17A/F responses in active TB distinguish it from cured or latent TB, suggesting therapeutic targeting of this pathway.

Transcriptional response modules characterise IL-1β and IL-6 activity in COVID-19

The paper identifies IL-1β and IL-6 transcriptional response modules in COVID-19 and finds they reflect cytokine bioactivity without correlating with disease severity.

Cerebrospinal fluid transcriptional analyses reveals upregulation of IL-17, Type 1 interferon transcriptional pathways and neutrophil persistence genes associated with increased mortality from pneumococcal meningitis in adults

The paper identifies CSF gene expression patterns associated with increased mortality in pneumococcal meningitis, highlighting IL-17, Type 1 interferon, and neutrophil persistence pathways.