Author

R. Heyderman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

J. A. Guerra-Assuncao· 2 shared J. S. Brown· 2 shared A. Gori· 1 shared A. W. Kamng'ona· 1 shared C. Brown· 1 shared C. Mwansambo· 1 shared C. Venturini· 1 shared D. Everett· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

J. A. Guerra-Assuncao

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Author profile →

3 papers

Recent·Most cited

Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae

E. Ramos Sevillano, G. Ercoli, M. Betts, J. A. Guerra-Assuncao, F. Partridge, V. Silva Entrudo Fernandes, E. Wall, S. Gordon, D. S. Ferreira, R. Heyderman, J. S. Brown

This study shows that one-carbon metabolism is essential for Streptococcus pneumoniae virulence, while proline biosynthesis has a strain-dependent role in systemic infection.

bioRxiv · Aug 3, 2023 · PreprintMicrobiology

Evaluation of pneumococcal serotyping in nasopharyngeal carriage isolates by latex agglutination, whole genome sequencing (PneumoCaT) and DNA microarray in a high pneumococcal carriage prevalence population in Malawi

T. D. Swarthout, A. Gori, N. Bar-Zeev, A. W. Kamng'ona, T. S. Mwalukomo, F. Bonomali, R. Nyirenda, C. Brown, J. Msefula, D. Everett, C. Mwansambo, K. Gould, J. Hinds, R. Heyderman, N. French

The paper evaluates three pneumococcal serotyping methods in Malawi, finding high concordance between latex agglutination, whole genome sequencing, and DNA microarray, with microarray improving detection of low-abundance vaccine serotypes.

bioRxiv · Aug 17, 2020Microbiology

Cerebrospinal fluid transcriptional analyses reveals upregulation of IL-17, Type 1 interferon transcriptional pathways and neutrophil persistence genes associated with increased mortality from pneumococcal meningitis in adults

E. C. Wall, J. A. Guerra-Assuncao, G. Pollara, C. Venturini, V. Mlowzowa, T. Allain, D. Lalloo, M. Noursadeghi, J. S. Brown, R. Heyderman

The paper identifies CSF gene expression patterns associated with increased mortality in pneumococcal meningitis, highlighting IL-17, Type 1 interferon, and neutrophil persistence pathways.

bioRxiv · Dec 7, 2018 · PreprintImmunology