C. Venturini

Single-cell transcriptome and T cell receptor profiling of the tuberculin skin test

The paper profiles single-cell transcriptomes and T cell receptors in human tuberculin skin tests to characterize the immune response to Mycobacterium tuberculosis.

The CSF transcriptome in pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality.

The study compares CSF and blood transcriptomes in pneumococcal meningitis patients to identify mortality-associated inflammatory responses.

A multi-scale clutch model for adhesion complex mechanics

The paper develops a multi-scale computational model of adhesion complexes to study how individual molecules respond to mechanical forces and control cell traction forces, aligning with experimental data.

A full computational model of cell motility: Early spreading, cell migration and competing taxis

This paper develops a computational model of cell motility that explains migration types and signal competition, showing chemotaxis dominates durotaxis but can be overridden under specific conditions.

Positive, negative and engineered durotaxis

This study explains positive and negative durotaxis through asymmetric cell adhesion dynamics and provides a framework to engineer cell migration.

L-form switching confers antibiotic, phage and stress tolerance in pathogenic Escherichia coli

This study shows that L-form switching in pathogenic E. coli provides tolerance to antibiotics, phages, and stress, with rapid reversion to the cell-walled state after antibiotic removal.

Exaggerated in vivo IL-17 responses discriminate recall responses in active TB

The paper shows that exaggerated IL-17A/F responses in active TB distinguish it from cured or latent TB, suggesting therapeutic targeting of this pathway.

Differential effects of antibiotic treatment with piperacillin/tazobactam or ceftriaxone on the murine gut microbiota

This study compares the effects of piperacillin/tazobactam and ceftriaxone on the murine gut microbiota, finding that ceftriaxone causes more prolonged dysbiosis and reduced colonization resistance.

Concise whole blood transcriptional signatures for incipient tuberculosis: A systematic review and patient-level pooled meta-analysis

This paper evaluates 17 mRNA signatures for predicting incipient tuberculosis using a pooled dataset of 1,026 samples, finding that eight signatures show moderate diagnostic accuracy but fall short of WHO benchmarks for long-term risk prediction.

K. pneumoniae ST258 genomic variability and bacteriophage susceptibility

The paper characterizes genomic variability in K. pneumoniae ST258 isolates and identifies phage susceptibility patterns, showing that effective phage therapy requires diverse phages targeting different capsule variants.

Epithelial micro-invasion by Streptococcus pneumoniae induces epithelial-derived innate immunity during colonisation at the human mucosal surface

This study shows that Streptococcus pneumoniae colonizes human mucosa via microinvasion, triggering epithelial innate immunity and influencing bacterial clearance.

Both the inflammatory response and clinical outcome differ markedly between adults with pneumococcal and meningococcal meningitis in a high HIV-1 prevalent setting in sub-Saharan Africa

This study compares inflammatory responses and clinical outcomes between pneumococcal and meningococcal meningitis in HIV-high prevalence settings, finding worse outcomes in pneumococcal cases.

Cerebrospinal fluid transcriptional analyses reveals upregulation of IL-17, Type 1 interferon transcriptional pathways and neutrophil persistence genes associated with increased mortality from pneumococcal meningitis in adults

The paper identifies CSF gene expression patterns associated with increased mortality in pneumococcal meningitis, highlighting IL-17, Type 1 interferon, and neutrophil persistence pathways.

Immune profiling of cord blood after prolonged rupture of membranes.

This study identifies transcriptomic changes in cord blood following prolonged rupture of membranes, suggesting immune responses to potential in utero infections.