J. S. Brown

The paper investigates whether adrenergic and mesenchymal phenotypes in neuroblastoma represent distinct cell types or dynamic cell states through theoretical modeling and hypothesis testing.

This study investigates how pneumococcal lipoproteins mediate epithelial microinvasion and finds that differential lipoprotein repertoires do not significantly impact microinvasion, suggesting post-translational modifications may be responsible.

This study shows that one-carbon metabolism is essential for Streptococcus pneumoniae virulence, while proline biosynthesis has a strain-dependent role in systemic infection.

This study shows P body factors coat germ granules in C. elegans to enable transgenerational gene silencing by maintaining small RNA factors and secondary small RNA amplification.

This study shows that GLH/VASA helicases are essential for forming germ granules, which ensure accurate piRNA-mediated transcriptome surveillance by distinguishing self from non-self.

This study applies a game-theoretic model to 590 Non-Small Cell Lung Cancer patients, showing it better fits tumor dynamics than classical models and predicts treatment outcomes.

The paper tests a female choice hypothesis for oak fertilization patterns, showing that maternal diversity indices fit the model better than random ovule selection.

This study presents a game-theoretic model showing that intraspecific competition can promote ecological specialization under specific conditions, contradicting the competitive diversification hypothesis.

This paper introduces a model of cancer progression based on coordination games, exploring their potential in understanding and treating cancer.

This paper develops a Markov chain model to optimize cancer treatment strategies by maximizing discounted expected quality of life years, considering patient preferences and treatment timing.

The paper develops a mathematical model showing that rapid oxygen fluctuations favor pseudohypoxia by selecting for constitutive HIF stabilization despite reduced cell fitness.

This study develops mathematical models to predict adaptive therapy benefits for metastatic melanoma, showing potential delays in progression by 6-25 months compared to continuous therapy.

This paper identifies high-affinity peptide binders for the SARS-CoV-2 spike protein using affinity selection-mass spectrometry, with nanomolar affinities and selectivity over human serum proteins.

This paper models population dynamics of obligate co-operators, showing that stable group dynamics lead to unstable population dynamics and eventual group collapse.

The paper describes a high school internship program in mathematical oncology, detailing its structure, curriculum, and outcomes over five years.

The paper explores the storage effect as a mechanism for intratumor heterogeneity, arguing that it may explain cancer diversity and inform therapy.

This study shows that competition between two breast cancer cell lines depends on frequency-dependent interactions, not just growth rates or carrying capacities.

This study analyzes how community saturation affects evolutionary dynamics in predator-prey and competition models, showing that under-saturation leads to instability and non-equilibrial behavior.

This study shows that germline RNA helicases regulate P granule formation and disassembly through RNA binding and release, with FGG repeats promoting perinuclear localization, and links defects in this process to fertility issues in C. elegans.

This study shows that Streptococcus pneumoniae colonizes human mucosa via microinvasion, triggering epithelial innate immunity and influencing bacterial clearance.

This study compares the biogeography of two nectarivorous bird families to assess the strength of their key adaptations, finding that hummingbirds occupy more extreme environments.

This study compares inflammatory responses and clinical outcomes between pneumococcal and meningococcal meningitis in HIV-high prevalence settings, finding worse outcomes in pneumococcal cases.

The paper studies how four desert rodents from two deserts respond to known and novel vipers, finding that post-exposure, all rodents perceived the heat-sensing sidewinder rattlesnake as a greater risk.