Mitochondrial energy dysfunction induces remodeling of the cardiac mitochondrial protein acylome
J. N. Peoples, N. Ghazal, D. M. Duong…·J. Q. Kwong
This study shows that mitochondrial energy dysfunction in the heart causes acylome remodeling, including increased acetylation and malonylation of mitochondrial proteins, with functional consequences for IDH2 and SIRT5.