Author

D. M. Korzhnev

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Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

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G. J. Valles· 1 shared I. Bezsonova· 1 shared N. Jaiswal· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBiophysics

G. J. Valles

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BiophysicsProceedings of the National Academy of SciencesPeer-reviewedMay 21, 2025

Activation Dynamics of Ubiquitin Specific Protease 7

G. J. Valles, N. Jaiswal, D. M. Korzhnev, I. Bezsonova

This study reveals that the isolated USP7 catalytic domain dynamically switches between inactive and active conformations in solution, with the active conformation pre-sampled even without substrate.

DOI 10.1073/pnas.2426632122

protein structureexperimental assay

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