Activation Dynamics of Ubiquitin Specific Protease 7
G. J. Valles, N. Jaiswal, D. M. Korzhnev, I. Bezsonova
This study reveals that the isolated USP7 catalytic domain dynamically switches between inactive and active conformations in solution, with the active conformation pre-sampled even without substrate.
bioRxiv · Jan 11, 2023Biophysics