BiochemistrybioRxiv
Targeting pathogenic Lafora bodies in Lafora disease using an antibody-enzyme fusion
M. K. Brewer, A. Uittenbogaard, G. L. Austin…·M. Gentry
This paper develops an antibody-enzyme fusion that degrades Lafora bodies in a mouse model of Lafora disease, reducing LB load and showing therapeutic potential.
DOI 10.1016/j.cmet.2019.07.002