Author

J. J. McCarthy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. B. Mobley· 2 shared A. Davidyan· 1 shared A. DePaoli-Roach· 1 shared A. K. Borowik· 1 shared A. Uittenbogaard· 1 shared B. Alkner· 1 shared B. F. Miller· 1 shared B. L. Hodges· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersPhysiology

C. B. Mobley

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Skeletal muscle nuclei in mice are not post-mitotic

A. K. Borowik, A. Davidyan, F. F. Peelor, E. Voloviceva, S. Doidge, M. P. Bubak, C. B. Mobley, J. J. McCarthy, E. E. Dupont-Versteegden, B. F. Miller

This study shows that skeletal muscle nuclei in mice can replicate in vivo through endoreplication, challenging the belief that they are post-mitotic.

bioRxiv · Oct 24, 2022Physiology

Genetic and Epigenetic Regulation of Skeletal Muscle Ribosome Biogenesis with Exercise

V. C. Figueiredo, Y. Wen, B. Alkner, R. Fernandez-Gonzalo, J. Norrbom, I. J. Vechetti, T. Valentino, C. B. Mobley, G. E. Zentner, C. A. Peterson, J. J. McCarthy, K. A. Murach, F. von Walden

This study examines how exercise affects ribosome biogenesis in skeletal muscle by analyzing genetic and epigenetic factors like rDNA copy number and methylation.

bioRxiv · Dec 14, 2020Cell Biology

Targeting pathogenic Lafora bodies in Lafora disease using an antibody-enzyme fusion

M. K. Brewer, A. Uittenbogaard, G. L. Austin, J. J. McCarthy, D. M. Segvich, A. DePaoli-Roach, P. J. Roach, B. L. Hodges, J. Zeller, J. R. Pauly, T. McKnight, D. Armstrong, M. Gentry

This paper develops an antibody-enzyme fusion that degrades Lafora bodies in a mouse model of Lafora disease, reducing LB load and showing therapeutic potential.

bioRxiv · Jun 21, 2019Biochemistry