Engineered developmental niche enables predictive phenotypic screening in human dystrophic cardiomyopathy
J. Macadangdang, J. W. Miklas, A. S. T. Smith, E. Choi, W. Leung, Y. Wang, X. Guan, S. Lee, M. R. Salick, M. Regnier, D. Mack, M. K. Childers, H. Ruohola-Baker, D.-H. Kim
This study develops an engineered cardiac niche to mature hPSC-derived cardiomyocytes, revealing arrhythmia in dystrophin mutants and identifying drug effects.
bioRxiv · Oct 29, 2018 · PreprintBioengineering