This paper constructs a single-cell atlas of circulating immune cells to understand inflammation across diseases and develops a classifier for inflammatory diseases.

bioRxiv · Nov 28, 2023Immunology

Macrophage and neutrophil heterogeneity at single-cell spatial resolution in inflammatory bowel disease

A. Garrido-Trigo, A. Corraliza, M. Veny, I. Dotti, E. Melon-Ardanaz, A. Rill, H. L. Crowell, A. Corbi, V. Gudino, M. Esteller, I. Alvarez-Teubel, D. Aguilar, M. C. Masamunt, E. Killingbeck, Y. Kim, , A. Salas

The paper identifies macrophage and neutrophil heterogeneity in inflammatory bowel disease using single-cell and spatial transcriptomics, revealing distinct subtypes and their potential roles in disease.

bioRxiv · Nov 28, 2022 · PreprintImmunology

An Atlas of Cells in the Human Tonsil

R. Massoni-Badosa, P. Soler-Vila, S. Aguilar-Fernandez, J. C. Nieto, M. Elosua-Bayes, D. Marchese, M. Kulis, A. Vilas-Zornoza, M. M. Bühler, S. Rashmi, C. Alsinet, G. Caratu, C. Moutinho, S. Ruiz, P. Lorden, , H. Heyn

The paper creates a comprehensive cell atlas of the human tonsil using single-cell multi-omics data, identifying 121 cell types and uncovering regulatory mechanisms and disease-related changes.

bioRxiv · Jun 24, 2022Immunology

A Single-Cell Tumor Immune Atlas for Precision Oncology

P. Nieto, M. Marc Elosua-Bayes, J. L. Trincado, D. Marchese, R. Massoni-Badosa, M. Salvany, A. Henriques, E. Mereu, C. Moutinho, S. Ruiz, P. Lorden, V. Chin, D. C. Kaczorowski, C.-L. Chan, R. Gallagher, , H. Heyn

The paper creates a single-cell tumor immune atlas using data from 217 patients and 13 cancer types to improve immune cell annotation and spatial mapping for precision oncology.

bioRxiv · Oct 26, 2020Cancer Biology