M. Esteller

This study shows that IκBα's chromatin activity, not its NF-κB signaling role, is critical for exiting naïve pluripotency in embryonic stem cells.

This study identifies ERBB4-mediated signaling as a mechanism of resistance to BTK and PI3K inhibitors in B cell lymphoid neoplasms and shows that targeting ERBB signaling can restore sensitivity.

The paper identifies macrophage and neutrophil heterogeneity in inflammatory bowel disease using single-cell and spatial transcriptomics, revealing distinct subtypes and their potential roles in disease.

This study shows that IκBα regulates hematopoietic stem cell (HSC) dormancy by controlling retinoic acid signaling during development.

The paper uses spatial transcriptomics to analyze Cancer Hallmarks in 63 tumors, revealing spatial patterns of hallmark activity and interdependencies between cancer and tumor microenvironment.

This study shows that TG-1801 enhances ublituximab's anti-lymphoma activity through GPR183-mediated mechanisms in B-NHL models.

This study identifies epimutations in Protein Phosphatase Enzymes and their interacting proteins in cancer tissues, showing their impact on clinical outcomes and therapeutic response.

This study identifies IL-17 as a key driver of age-related skin inflammation and shows that blocking IL-17 signaling reduces inflammatory markers and delays aging traits in skin.

This study compares MeCP2-E1 and E2 isoforms, showing differences in DNA binding, protein interactions, and dynamic behavior, with implications for their functional roles in chromatin regulation.