H. Heyn

Integrative single-cell multi-omics of CD19CARpos and CARneg T cells suggest drivers of immunotherapy response in B-cell neoplasias

This study integrates single-cell multi-omics data from CAR-T cells to identify factors influencing immunotherapy response in B-cell neoplasias.

scDrugPrio: A framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases

scDrugPrio uses single-cell RNA sequencing to prioritize drugs for immune-mediated inflammatory diseases, showing personalized drug response variations across patients.

Quantifying Adaptive Evolution of the Human Immune Cell Landscape

The paper quantifies adaptive evolution in human immune cell types and states, finding elevated adaptation rates in specific cell types and early immune responses.

The cellular landscape of the endochondral bone during the transition to extrauterine life

This study profiles the single-cell composition of murine endochondral bone during the perinatal transition, identifying fibroblastic clusters and dynamic interactions relevant to skeletogenesis and immune development.

Macrophage and neutrophil heterogeneity at single-cell spatial resolution in inflammatory bowel disease

The paper identifies macrophage and neutrophil heterogeneity in inflammatory bowel disease using single-cell and spatial transcriptomics, revealing distinct subtypes and their potential roles in disease.

β-catenin activity induces an RNA biosynthesis program promoting therapy resistance in T Acute Lymphoblastic Leukemia

The paper identifies a β-catenin-regulated RNA biosynthesis program linked to therapy resistance in T-ALL and suggests combining chemotherapy with β-catenin inhibitors to improve treatment outcomes.

An Atlas of Cells in the Human Tonsil

The paper creates a comprehensive cell atlas of the human tonsil using single-cell multi-omics data, identifying 121 cell types and uncovering regulatory mechanisms and disease-related changes.

A comprehensive single-cell expression atlas of human AML leukemia-initiating cells unravels the contribution of HIF pathway and its therapeutic potential

The paper creates a single-cell atlas of AML leukemia-initiating cells and shows that targeting the HIF pathway enhances chemotherapy effectiveness against these cells.

Local IL-17 orchestrates skin aging

This study identifies IL-17 as a key driver of age-related skin inflammation and shows that blocking IL-17 signaling reduces inflammatory markers and delays aging traits in skin.

Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses

The paper creates a single-cell atlas of CVID, identifying epigenetic and transcriptional defects in memory B cells and linking them to impaired cell communication.

Glioblastoma cell fate is differentially regulated by the microenvironments of the tumour bulk and infiltrative margin

This study compares glioblastoma cell fate in tumour bulk and margin, finding distinct neurogenic patterns and immune environments, with margin cells showing developmental-like trajectories and iNPCs linked to interferon signalling.

Siglec-1 on dendritic cells mediates SARS-CoV-2 trans-infection of target cells while on macrophages triggers proinflammatory responses

This study shows Siglec-1 on APCs mediates SARS-CoV-2 trans-infection and triggers proinflammatory responses, suggesting it as a potential therapeutic target.

A Single-Cell Tumor Immune Atlas for Precision Oncology

The paper creates a single-cell tumor immune atlas using data from 217 patients and 13 cancer types to improve immune cell annotation and spatial mapping for precision oncology.