S. Ruiz

CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia

This study identifies CDK6-driven cell cycle acceleration in endothelial cells as a driver of arteriovenous malformations in HHT, suggesting CDK4/6 inhibitors as potential therapeutic options.

3D-intrusions transport active surface microbial assemblages to the dark ocean

The paper shows that ocean subduction creates 3D intrusions transporting surface microbial communities into the dark ocean, altering deep-sea microbial composition and carbon cycling.

Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10

This study shows oxidative stress induces VE-cadherin proteolysis via MMPs and γ-secretase in HUVECs, with BMP9/10 reducing this effect and protecting against apoptosis.

An Atlas of Cells in the Human Tonsil

The paper creates a comprehensive cell atlas of the human tonsil using single-cell multi-omics data, identifying 121 cell types and uncovering regulatory mechanisms and disease-related changes.

Glioblastoma cell fate is differentially regulated by the microenvironments of the tumour bulk and infiltrative margin

This study compares glioblastoma cell fate in tumour bulk and margin, finding distinct neurogenic patterns and immune environments, with margin cells showing developmental-like trajectories and iNPCs linked to interferon signalling.

Vaccination with SARS-CoV-2 Spike Protein and AS03 Adjuvant Induces Rapid Anamnestic Antibodies in the Lung and Protects Against Virus Challenge in Nonhuman Primates

This study shows that an AS03-adjuvanted SARS-CoV-2 spike protein vaccine induces strong antibody responses and protects nonhuman primates from viral challenge.

A Single-Cell Tumor Immune Atlas for Precision Oncology

The paper creates a single-cell tumor immune atlas using data from 217 patients and 13 cancer types to improve immune cell annotation and spatial mapping for precision oncology.

GRP78 promotes stemness in normal and neoplastic cells

This study identifies GRP78 as a marker of stem-like properties in breast cancer cells, showing its role in promoting stemness and metastatic potential.

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer disease and three causality networks of AD: the GR@ACE project.

The paper performs a genome-wide association study of dementia and its endophenotypes, identifying novel loci and causal networks related to Alzheimer's disease.

Sirolimus plus nintedanib treats vascular pathology in HHT mouse models

This study shows that combining sirolimus and nintedanib treats vascular abnormalities in HHT mouse models by targeting multiple pathways.

Tacrolimus Rescues Endothelial ALK1 Loss-Of-Function Signaling And Improves HHT Vascular Pathology

This study identifies tacrolimus as a drug that activates Smad1/5/8 signaling and reduces vascular pathology in HHT models.

A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10

This study uses transmammary delivery of anti-BMP9/10 antibodies to induce HHT-like vascular defects in mouse neonates, revealing consistent retinal pathology and increased angiopoietin-2 expression.