Author

D. Mott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

S. M. Behar· 3 shared C. M. Sassetti· 2 shared J. Yang· 2 shared A. J. Olive· 1 shared B. Stowell· 1 shared C. Baer· 1 shared F. Rosa· 1 shared G. Babunovic· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersImmunology

S. M. Behar

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3 papers

Recent·Most cited

High bacillary burden and the ESX-1 type VII secretion system promote MHC class I presentation by Mycobacterium tuberculosis infected macrophages to CD8 T-cells

D. Mott, J. Yang, C. Baer, K. Papavinasasundaram, C. M. Sassetti, S. M. Behar

The paper shows high Mtb burden in macrophages leads to cell death and cross-presentation of TB10.4 antigen to CD8 T-cells via the ESX-1 system, promoting immune response but potentially worsening immunopathology.

bioRxiv · Oct 20, 2022 · PreprintImmunology

Mitochondrial respiration contributes to the interferon gamma response in antigen presenting cells

M. Kiritsy, D. Mott, S. M. Behar, C. M. Sassetti, A. J. Olive

This study identifies mitochondrial respiration as essential for the interferon gamma response in antigen presenting cells, showing that complex I inhibition blocks T cell activation.

bioRxiv · Nov 22, 2020Immunology

Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages

J. Yang, D. Mott, R. Sutiwisesak, Y. J. Lu, F. Rosa, B. Stowell, G. Babunovic, J. Lee, S. Carpenter, S. S. Way, S. Fortune, S. M. Behar

This study compares CD4+ and CD8+ T cell recognition of Mtb-infected macrophages, finding CD8+ T cells poorly recognize infected macrophages despite strong immunodominant responses.

bioRxiv · Feb 20, 2018Immunology