S. Carpenter

Ancient origin of an urban underground mosquito

The paper shows that the London Underground Mosquito adapted to human environments aboveground in the Middle East over 1000 years, not recently underground in London.

Human long noncoding RNA, VILMIR, is induced by major respiratory viral infections and modulates the host interferon response

This study identifies VILMIR, a novel lncRNA upregulated by respiratory viral infections and IFN-β, which modulates the host interferon response.

Evolutionarily conserved effects of Notch signaling drive intestinal graft-versus-host disease in mice and non-human primates

This study shows that Notch signaling, specifically through DLL4, promotes intestinal GVHD in mice and non-human primates by enhancing effector T-cell infiltration and reducing regulatory T-cell activity.

Natural reassortment of a segmented RNA arbovirus illustrates plasticity of phenotype in the arthropod vector and mammalian host in vivo

This study investigates reassortment in bluetongue virus, showing how it affects vector competence and virulence in natural settings.

LincRNA-Cox2 functions to regulate inflammation in alveolar macrophages during acute lung injury.

This study identifies lincRNA-Cox2 as a regulator of immune gene expression in alveolar macrophages during acute lung injury using RNA-seq and transgenic mice.

Isoform-level transcriptome Atlas of Macrophage Activation

The paper generates an isoform-level transcriptome atlas of macrophage activation using long-read sequencing, providing full-length isoform information for primary human macrophages.

Inflammation Drives Alternative First Exon usage to Regulate Immune Genes including a Novel Iron Regulated Isoform of Aim2

The paper identifies inflammation-induced alternative first exon usage in immune genes, revealing a novel iron-regulated Aim2 isoform with a 5′UTR iron-responsive element.

Generation and utilization of a HEK-293T murine GM-CSF expressing cell line

The paper generates a HEK-293T cell line expressing murine GM-CSF and shows it supports dendritic cell and alveolar macrophage differentiation as an alternative to commercial GM-CSF.

High throughput CRISPR screening identifies genes involved in macrophage viability and inflammatory pathways

The paper uses CRISPR screening to identify genes essential for macrophage viability and regulators of inflammatory pathways like NF-κB and TNF signaling.

Transcription factor NF-κB in a basal metazoan, the sponge, has conserved and unique sequences, activities, and regulation

This study characterizes the NF-κB protein in the sponge Amphimedon queenslandica, showing conserved features with vertebrates but distinct regulatory mechanisms.

A strain of an emerging Indian pathotype of Xanthomonas oryzae pv. oryzae defeats the rice bacterial blight resistance gene xa13 without inducing a clade III SWEET gene and is nearly identical to a recent Thai isolate

The paper identifies an Xoo strain that bypasses xa13 resistance by not inducing clade III SWEET genes and is nearly identical to a Thai isolate.

Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages

This study compares CD4+ and CD8+ T cell recognition of Mtb-infected macrophages, finding CD8+ T cells poorly recognize infected macrophages despite strong immunodominant responses.