Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging
J. Mahadevan, A. Jha, J. Rudolph, S. Bowerman, D. Narducci, A. S. Hansen, K. Luger
This study uses live-cell single-molecule imaging to show that most PARP1/2 diffuse freely, with a small fraction transiently binding DNA after damage, suggesting new strategies for PARP inhibitors.
bioRxiv · Mar 12, 2022Biophysics