Author

J. Mahadevan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:fluorescence / live-cell microscopy· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Rudolph· 5 shared K. Luger· 5 shared A. Jha· 3 shared S. Bowerman· 3 shared A. S. Hansen· 1 shared D. Narducci· 1 shared E. M. Grumstrup· 1 shared G. Gaullier· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersBiophysics

J. Rudolph

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Automated Modeling of Protein Accumulation at DNA Damage Sites using qFADD.py

S. Bowerman, J. Mahadevan, P. Benson, J. Rudolph, K. Luger

The paper introduces qFADD.py, an open-source tool for analyzing DNA damage repair protein dynamics using automated fitting and simulation, improving upon previous methods with better statistical rigor and user-friendliness.

Biological Imaging · Aug 30, 2022Peer-reviewedBiophysics

Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging

J. Mahadevan, A. Jha, J. Rudolph, S. Bowerman, D. Narducci, A. S. Hansen, K. Luger

This study uses live-cell single-molecule imaging to show that most PARP1/2 diffuse freely, with a small fraction transiently binding DNA after damage, suggesting new strategies for PARP inhibitors.

bioRxiv · Mar 12, 2022Biophysics

Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1

G. Gaullier, G. Roberts, U. M. Muthurajan, S. Bowerman, J. Rudolph, J. Mahadevan, A. Jha, P. S. Rae, K. Luger

The paper presents a cryo-EM structure of PARP2 bridging nucleosome-proximal DNA breaks and shows its interaction with HPF1 in a functional complex.

bioRxiv · Nov 18, 2019Biochemistry

Q-FADD: A mechanistic approach for modeling the accumulation of proteins at sites of DNA damage by free diffusion

J. Mahadevan, J. Rudolph, A. Jha, J. W. Tay, J. Dragavon, E. M. Grumstrup, K. Luger

The paper introduces a free diffusion model to quantify protein accumulation at DNA damage sites in live cells, applied to poly-ADP-ribose polymerases 1 and 2.

bioRxiv · Jul 20, 2018Biochemistry

Poly(ADP-ribose) polymerase 1 Searches DNA via a ‘Monkey Bar’ Mechanism

J. Rudolph, J. Mahadevan, P. N. Dyer, K. Luger

This study reveals that PARP1 searches DNA using a 'monkey bar' mechanism, where DNA binding facilitates release, and identifies the WGR-domain as essential for this process.

bioRxiv · May 18, 2018Biophysics