Author

S. Bowerman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Approach:experimental assay· 2 Assay:fluorescence / live-cell microscopy· 2 Approach:microscopy & imaging analysis· 2 Approach:Bayesian inference· 1

Frequent Co-Authors

K. Luger· 4 shared J. Mahadevan· 3 shared J. Rudolph· 3 shared A. Jha· 2 shared J. Wereszczynski· 2 shared A. S. Hansen· 1 shared D. Narducci· 1 shared E. H. Brookes· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersBiophysics

K. Luger

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Automated Modeling of Protein Accumulation at DNA Damage Sites using qFADD.py

S. Bowerman, J. Mahadevan, P. Benson, J. Rudolph, K. Luger

The paper introduces qFADD.py, an open-source tool for analyzing DNA damage repair protein dynamics using automated fitting and simulation, improving upon previous methods with better statistical rigor and user-friendliness.

Biological Imaging · Aug 30, 2022Peer-reviewedBiophysics

Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging

J. Mahadevan, A. Jha, J. Rudolph, S. Bowerman, D. Narducci, A. S. Hansen, K. Luger

This study uses live-cell single-molecule imaging to show that most PARP1/2 diffuse freely, with a small fraction transiently binding DNA after damage, suggesting new strategies for PARP inhibitors.

bioRxiv · Mar 12, 2022Biophysics

Archaeal chromatin 'slinkies' are inherently dynamic complexes with deflected DNA wrapping pathways

S. Bowerman, J. Wereszczynski, K. Luger

This study characterizes the dynamic structure of archaeal chromatin complexes using simulations and cryoEM, revealing their inherent flexibility and DNA wrapping patterns.

bioRxiv · Dec 8, 2020Biophysics

Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1

G. Gaullier, G. Roberts, U. M. Muthurajan, S. Bowerman, J. Rudolph, J. Mahadevan, A. Jha, P. S. Rae, K. Luger

The paper presents a cryo-EM structure of PARP2 bridging nucleosome-proximal DNA breaks and shows its interaction with HPF1 in a functional complex.

bioRxiv · Nov 18, 2019Biochemistry

BEES: Bayesian Ensemble Estimation from SAS

S. Bowerman, J. E. Curtis, J. Clayton, E. H. Brookes, J. Wereszczynski

BEES is a Bayesian tool for fitting ensemble models to SAS data, allowing users to sample and compare models while incorporating additional data.

bioRxiv · Feb 9, 2019Biophysics