ImmunologybioRxiv
The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function
I. P. Foskolou, P. P. Cunha, E. Minogue…·R. S. Johnson
This study shows S-2HG and R-2HG differentially regulate CD8+ T cell function, with S-2HG enhancing anti-tumour activity and T cell fitness.
DOI 10.1016/j.celrep.2023.113013