Protein Translation Dysregulation and Immune Cell Evasion Define Metastatic Clones in HPV-related Cancer of the Oropharynx
V. Chin, W. Muskovic, R. A. McCloy, D. Neavin, J. Alquicira, H. Arora, A. Senabouth, P. Keith, E. Spenceley, A. Murphy, D. Kaczorowski, P. Floros, P. Earls, B. Leavers, J. Crawford, , J. Powell
This study identifies mechanisms of immune evasion and metastasis in HPV-related oropharyngeal cancer using single-cell and spatial genomic data, showing dysregulated protein translation and immune pathway suppression in metastatic clones.
bioRxiv · Apr 15, 2024 · PreprintCancer Biology