A. Murphy

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

Protein Translation Dysregulation and Immune Cell Evasion Define Metastatic Clones in HPV-related Cancer of the Oropharynx

This study identifies mechanisms of immune evasion and metastasis in HPV-related oropharyngeal cancer using single-cell and spatial genomic data, showing dysregulated protein translation and immune pathway suppression in metastatic clones.

Conditional c-MYC activation in catecholaminergic cells drives distinct neuroendocrine tumors: neuroblastoma vs somatostatinoma

This study creates two mouse models with conditional c-MYC activation in specific cell types, leading to distinct neuroendocrine tumors resembling human neuroblastoma and somatostatinoma.

Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.

The target gene regulatory network of miR-497 in angiosarcoma

This study identifies miR-497 as a tumor suppressor in angiosarcoma by regulating target genes like CCND2, CDK6, and VAT1, with VAT1 inhibition reducing tumor migration.

Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor

This study shows JMJD6 links pre-mRNA splicing and metabolism in MYC-driven cancers, and its inhibition enhances therapeutic response to splicing inhibitors.

Meta-exoproteomics identifies active plant-microbe interactions operating in the rhizosphere

This study uses meta-exoproteomics to identify active plant-microbe interactions in the rhizosphere of Brassica spp., revealing metabolic shifts linked to plant growth.

Rethinking habitat occupancy modeling and the role of diel activity in an anthropogenic world

The paper develops a new occupancy model to analyze diel activity patterns of species in response to human disturbance and finds that both fosa and coyote adjust their habitat use across diel states and years.

Phosphorus stress induces the synthesis of novel glycolipids in Pseudomonas aeruginosa that confer protection against a last-resort antibiotic

This paper shows that Pseudomonas aeruginosa produces novel glycolipids under phosphorus stress, which protect it from polymyxin B antibiotic.

Modelling Human Gait using a Nonlinear Differential Equation

The paper models human gait using a nonlinear differential equation based on 3D visualization of center of mass movement during walking or running.

A novel class of sulfur-containing aminolipids widespread in marine roseobacters

The paper identifies and characterizes a novel sulfur-containing aminolipid in marine roseobacters, showing its role in biofilm formation and widespread distribution in Tara Oceans metagenomes.

Common genetic variation in humans impacts in vitro susceptibility to SARS-CoV-2 infection

This study shows that a common genetic variant in the FURIN gene affects SARS-CoV-2 infection in vitro, suggesting genetic factors contribute to clinical variability in COVID-19.

KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

This study shows KDM6B promotes oncogenic CDK4/6-pRB-E2F pathway activation in neuroblastoma by maintaining enhancer activity, and its inhibition correlates with poor patient survival.

A micro-PRNT for the detection of Ross River virus antibodies in mosquito blood meals: a useful tool for inferring transmission pathways

This paper develops and validates a micro-PRNT method to detect Ross River virus antibodies in mosquito blood meals, enabling inference of transmission pathways.

Novel mechanisms for phosphate acquisition in abundant rhizosphere-dwelling Bacteroidetes

This study identifies novel phosphate mobilization mechanisms in Flavobacterium strains from the rhizosphere, including unique phosphatases, hypothetical genes, and SusCD transporters.

Interpreting mosquito feeding patterns in Australia through an ecological lens; an analysis of blood meal studies.

This study analyzes mosquito feeding patterns in Australia using blood meal data to identify species-specific feeding associations and their implications for disease ecology.