J. Powell

Adult-type diffuse gliomas share recurring cell states driven by a common astrocyte-like glioma stem cell population

This study identifies recurring cell states across adult-type diffuse gliomas and reveals a shared astrocyte-like glioma stem cell population driving intratumoural heterogeneity.

A DNA-based molecular clamp for probing protein interactions and structure under force.

The paper develops a DNA-based molecular clamp to apply tension to proteins and study their interactions and structure under force.

Protein Translation Dysregulation and Immune Cell Evasion Define Metastatic Clones in HPV-related Cancer of the Oropharynx

This study identifies mechanisms of immune evasion and metastasis in HPV-related oropharyngeal cancer using single-cell and spatial genomic data, showing dysregulated protein translation and immune pathway suppression in metastatic clones.

Discovery and characterization of chromosomal inversions in the arboviral vector mosquito Aedes aegypti

This study identifies chromosomal inversions in Aedes aegypti using Hi-C, revealing geographic distribution patterns and potential roles in host choice and disease transmission.

The distinct translational landscapes of Gram-positive and Gram-negative bacteria

This study compares translational mechanisms in Gram-negative Salmonella and Gram-positive Listeria, revealing distinct regulatory features affecting protein synthesis efficiency.

An experimental comparison of the Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research

This study compares Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research, finding differences in sensitivity, specificity, and application suitability.

Distinct Myeloid Derived Suppressor Cell Populations Promote Tumor Aggression in Glioblastoma

This study identifies two unique myeloid-derived suppressor cell populations in glioblastoma that promote tumor growth and immune evasion.

Nitrogen niche partitioning between tropical legumes and grasses conditionally weakens under elevated CO2

This study examines how nitrogen niche partitioning between tropical legumes and grasses affects over-yielding under elevated CO2, finding that niche partitioning and over-yielding decrease in mixtures under higher CO2.

Phosphorus availability and arbuscular mycorrhizal fungi limit soil C cycling and influence plant responses to elevated CO2 conditions.

This study investigates how phosphorus availability and arbuscular mycorrhizal fungi affect soil carbon cycling and plant responses under elevated CO2 conditions, finding that these factors act independently.

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

This study shows that delayed type I and III interferon responses in nasal epithelial cells allow SARS-CoV-2 replication, but pre-infection IFN treatment restricts virus and preserves barrier integrity.

Non-clinical safety profile and pharmacodynamics of two formulations of the anti-sepsis drug candidate Rejuveinix

This study shows two Rejuveinix formulations have a favorable safety profile in rats and similarly increase antioxidant levels in tissues, indicating bioequivalence.

A Single-Cell Tumor Immune Atlas for Precision Oncology

The paper creates a single-cell tumor immune atlas using data from 217 patients and 13 cancer types to improve immune cell annotation and spatial mapping for precision oncology.

Evolving Transcriptomic Signature of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cells With Age

This study characterizes the transcriptomic changes in hPSC-derived RPE cells over time in culture, showing a maturing transcriptional profile that resembles native RPE.

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

This study identifies diverse stromal subsets in TNBC using single-cell RNA-seq and links them to immune evasion mechanisms and therapeutic targets.

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis

This study shows that cryopreservation of human cancers preserves tumour heterogeneity for single-cell multi-omics analysis, with comparable results to fresh tissue.

Detection of HPV E7 transcription at single-cell resolution in epidermis

The paper uses scRNA-seq to detect HPV16-E7 mRNA in mouse keratinocytes, showing its association with gene expression and potential for identifying HPV involvement in cancer.