M. Arnold

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

The HuMet Repository: Watching human metabolism at work

The HuMet Repository provides time-resolved metabolomics data from six metabolic challenges in healthy males, enabling analysis of dynamic metabolic responses and pathway interactions.

Mechanisms underlying the efficacy of a rodent model of vertical sleeve gastrectomy - a focus on energy expenditure

This study investigates the role of brown adipose tissue thermogenesis in the efficacy of vertical sleeve gastrectomy in rodents, showing its impact on weight loss and glucose regulation.

Ribonucleotide reductase, a novel target for gonorrhea

This study identifies two novel inhibitors of Neisseria gonorrhoeae that target ribonucleotide reductase, showing efficacy against multidrug-resistant strains in a mouse model.

The Vagus Nerve Mediates the Physiological but not Pharmacological Effects of PYY3-36 on Food Intake

This study shows that PYY3-36's physiological effects on food intake depend on the vagus nerve's Y2R, but pharmacological effects are not affected.

Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targets

This study characterizes treatment-induced high-grade gliomas (TIHGGs) through molecular profiling, identifying distinct subgroups and potential therapeutic targets.

Acylcarnitine Metabolomic Profiles Inform Clinically-Defined Major Depressive Phenotypes

This study identifies distinct acylcarnitine metabolomic profiles associated with different subtypes of major depressive disorder following SSRI treatment.