D. Neumeier

Generation of a single-cell B cell atlas of antibody repertoires and transcriptomes to identify signatures associated with antigen-specificity

The paper generates a single-cell B cell atlas to link antibody repertoires, transcriptomes, and antigen specificity in murine immunization models.

The Physiological Landscape and Specificity of Antibody Repertoires

This study analyzes antibody repertoires across multiple lymphoid organs in immunized mice, finding that strong humoral responses lead to consolidated, overlapping B-cell clones and a uniform but redundant physiological landscape.

Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cells

This study investigates whether clonal expansion of plasma cells is deterministic or stochastic by analyzing antigen-specificity, affinity, and epitope convergence in antibody repertoires.

Clonally expanded virus-specific CD8 T cells acquire diverse transcriptional phenotypes during acute, chronic, and latent infections

This study examines clonal expansion and transcriptional diversity in virus-specific CD8 T cells across different infection stages using single-cell sequencing and a new bioinformatic tool.

Single-cell sequencing reveals clonally expanded plasma cells during chronic viral infection produce virus-specific and cross-reactive antibodies

Platypus: an open-access software for integrating lymphocyte single-cell immune repertoires with transcriptomes

Platypus integrates single-cell immune repertoires with transcriptomes to analyze lymphocyte features and transcriptional profiles in convalescent COVID-19 patients.

Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice

This study uses single-cell sequencing to show that aged mouse brains have clonally expanded and transcriptionally distinct lymphocytes, potentially contributing to neuroinflammation.

Convergent selection in antibody repertoires is revealed by deep learning

This study uses deep learning to identify convergent antibody sequences in mice, showing their antigen-specificity and potential for immunodiagnostics.